CELL SURFACE PROTEIN INTERACTOMICS
TECHNOLOGY
The dynamic cell surface protein interactome is essential to understanding the molecular mechanisms of cell function. This aspect of cell biology is largely unexplored due to the lack of high-throughput, high-multiplex spatial proteomics technologies.
Discover the molecular basis of cell function through protein interactomics by Proximity Networks
Proteins work together on the cell surface by clustering or forming multi-protein domains to control cell function. The groundbreaking Proximity Network Assay enables high-throughput mapping of the dynamic protein interactome of the cell surface of single cells. With nanoscale resolution averaging 50nm, individual proteins are connected together to form a spatial network of the location of cell surface targets. Protein colocalization, clustering, and abundance are reported on a single cell level providing the understanding of proteomic differences in heterogeneous cell populations.
Proximity Network Assay - How it works
Key Features & Benefits
Mapping the protein interactome at scale
The Proximity Network Assay provides new insights into the basis of cellular function by generating nanoscale protein interactomics data analyzing 155 cell surface target markers in parallel.
Unprecedented spatial resolution and throughput
Creating a detailed network of surface protein markers at a resolution of ~50nm where the panel proteins are directly connected with all its neighbors.
Functional protein cluster rearrangement analysis
Provides new hypotheses into cellular function at the molecular level by uncovering multi-protein cluster rearrangements for different disease states, drug response and cell activation stages.
Cell to cell interaction quantification
Detects which cells in a cell suspension are interacting to better understand immune system cell communication, activity and trogocytosis.
Leverage Your Existing NGS Workflow
Obtain powerful single cell protein abundance, clustering, and colocalization data with a simple, scalable solution available to any molecular biology laboratory.